Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
Identifieur interne : 001E12 ( Main/Exploration ); précédent : 001E11; suivant : 001E13Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
Auteurs : Golakoti Trimurtulu [États-Unis] ; D. John Faulkner [États-Unis] ; Nigel B. Perry [Nouvelle-Zélande] ; Laurent Ettouati [Nouvelle-Zélande] ; Marc Litaudon [Nouvelle-Zélande] ; John W. Blunt [Nouvelle-Zélande] ; Murray H. G. Munro [Nouvelle-Zélande] ; Geoffrey B. Jameson [États-Unis]Source :
- Tetrahedron [ 0040-4020 ] ; 1994.
English descriptors
- Teeft :
- Baker bond, Bond lengths, Cape armitage, Carbon signal, Carbon signals, Cell line, Cosy spectrum, Enhancement, Hydrogen atoms, Mcmurdo sound, Meoh, Moiety, Molecular formula, Noeds experiment, Organic layer, Pyridine ring, Reaction mixture, Room temperature, Screening data, Sephadex, Silver oxide, Sponge kirkpatrickia variufosa, Tetrahydrovariolin, Variolin.
Abstract
Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.
The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data.gr1
Url:
DOI: 10.1016/S0040-4020(01)89674-5
Affiliations:
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Perry</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Chemistry, University of Canterbury, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Ettouati, Laurent" sort="Ettouati, Laurent" uniqKey="Ettouati L" first="Laurent" last="Ettouati">Laurent Ettouati</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Chemistry, University of Canterbury, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Chemistry, University of Canterbury, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Blunt, John W" sort="Blunt, John W" uniqKey="Blunt J" first="John W." last="Blunt">John W. Blunt</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Chemistry, University of Canterbury, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Munro, Murray H G" sort="Munro, Murray H G" uniqKey="Munro M" first="Murray H. G." last="Munro">Murray H. G. Munro</name><affiliation wicri:level="1"><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Chemistry, University of Canterbury, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Jameson, Geoffrey B" sort="Jameson, Geoffrey B" uniqKey="Jameson G" first="Geoffrey B" last="Jameson">Geoffrey B. 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N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.</div><div type="abstract">The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data.gr1 </div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li><li>États-Unis</li></country><region><li>Californie</li><li>District de Columbia</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Trimurtulu, Golakoti" sort="Trimurtulu, Golakoti" uniqKey="Trimurtulu G" first="Golakoti" last="Trimurtulu">Golakoti Trimurtulu</name></region><name sortKey="Faulkner, D John" sort="Faulkner, D John" uniqKey="Faulkner D" first="D. John" last="Faulkner">D. John Faulkner</name><name sortKey="Jameson, Geoffrey B" sort="Jameson, Geoffrey B" uniqKey="Jameson G" first="Geoffrey B" last="Jameson">Geoffrey B. Jameson</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Perry, Nigel B" sort="Perry, Nigel B" uniqKey="Perry N" first="Nigel B." last="Perry">Nigel B. Perry</name></noRegion><name sortKey="Blunt, John W" sort="Blunt, John W" uniqKey="Blunt J" first="John W." last="Blunt">John W. Blunt</name><name sortKey="Ettouati, Laurent" sort="Ettouati, Laurent" uniqKey="Ettouati L" first="Laurent" last="Ettouati">Laurent Ettouati</name><name sortKey="Litaudon, Marc" sort="Litaudon, Marc" uniqKey="Litaudon M" first="Marc" last="Litaudon">Marc Litaudon</name><name sortKey="Munro, Murray H G" sort="Munro, Murray H G" uniqKey="Munro M" first="Murray H. G." last="Munro">Murray H. G. Munro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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